Acute shear stress direction dictates adherent cell remodeling and verifies shear profile of spinning disk assays

Flow (shear stress)-mediated remodeling of resistance arteries in diabetes.

Shear stress due to blood flow is the most important force stimulating vascular endothelium. Acute stimulation of the endothelium by shear stress induces a vasodilatation mainly due to the release of nitric oxide (NO) among other relaxing agents. After a chronic increase in blood flow (shear stress), the endothelium triggers diameter enlargement, medial hypertrophy and improvement of arterial c...

Complex roles of endothelial shear stress in vascular remodeling response.

improves vascular endothelial and cardiac function in patients with chronic heart failure. J Am Coll Cardiol 2002;39:754–9. 4. Akasaki Y, Miyata M, Eto H, et al. Repeated thermal therapy up-regulates endothelial nitric oxide synthase and augments angiogenesis in a mouse model of hindlimb ischemia. Circ J 2006:70;463–70. 5. Aicher A, Heeschen C, Mildner-Rihm C, et al. Essential role of endotheli...

Endothelial actin cytoskeleton remodeling during mechanostimulation with fluid shear stress.

Fluid shear stress stimulation induces endothelial cells to elongate and align in the direction of applied flow. Using the complementary techniques of photoactivation of fluorescence and fluorescence recovery after photobleaching, we have characterized endothelial actin cytoskeleton dynamics during the alignment process in response to steady laminar fluid flow and have correlated these results ...

Platelets and shear stress.

C LINICAL BLEEDING or thrombosis results from a disturbance in the balance between a complex network of procoagulant and anticoagulant factors. This network involves three primary interactions, first described by the eminent pathologist Rudolph Virchow during the previous century, between blood (soluble and cellular constituents), the blood vessel (including fixed and dynamic responses), and bl...

Endothelial Shear Stress: A Critical Determinant of Arterial Remodeling and Arterial Stiffness in Humans. A Carotid 3.0 Tesla MRI Study. Running Title: Shear Stress, Arterial Remodeling and Stiffness